Glossary

Men’s sexual health, defined

54 terms in plain English, from semen volume to SHBG. Each one links to the research behind it.

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Erections & performance PDE5 inhibitors PDE5 inhibitors are prescription medicines, including sildenafil, tadalafil, vardenafil and avanafil, that treat erectile dysfunction by strengthening the penis's natural response to sexual stimulation. They need a prescriber and must never be combined with nitrate medicines. Erections & performance Pelvic floor The pelvic floor is a sling of muscles across the base of the pelvis. In men it supports the abdominal organs, helps control urine and bowels, and is active during sex, and training it can improve erections and bladder control. Erections & performance Performance anxiety Sexual performance anxiety is worry about how you'll perform in bed: whether you'll get hard, last long enough or satisfy a partner. It's common, and it can create the very erection and ejaculation problems it fears. Semen & ejaculation Pre-ejaculate Pre-ejaculate is the clear, slippery fluid that appears at the tip of the penis during arousal, before ejaculation. It comes mainly from the Cowper's glands and often contains no sperm, but studies have found moving sperm in some men's samples. Erections & performance Premature ejaculation Premature ejaculation (PE) means regularly ejaculating sooner than you want: within about a minute of penetration since your first sexual experiences, or after a bothersome drop to around three minutes or less, with little control and real distress. Hormones Prolactin Prolactin is a pituitary hormone best known for milk production, but men make it too. It surges after orgasm, and persistently high levels, called hyperprolactinaemia, can flatten sex drive and cause erection problems. Semen & ejaculation Prostate The prostate is a walnut-sized gland below the bladder that wraps around the urethra. It adds about a quarter of the fluid in semen, rich in zinc, citrate and PSA, the enzyme that thins semen after ejaculation.

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Supplements & nutrients Selenium Selenium is a trace mineral that contributes to normal spermatogenesis, the production of sperm. In a trial of subfertile men with low selenium status, supplements improved sperm motility. Food sources include Brazil nuts, fish and eggs, and high intakes carry safety risks. Sperm & fertility Semen analysis A semen analysis is a laboratory test of a semen sample that measures volume, sperm concentration, total count, motility and morphology. It is the first-line test of male fertility, and an abnormal result is usually repeated before any conclusions are drawn. Semen & ejaculation Semen volume Semen volume is the amount of fluid released in a single ejaculation. Most of it comes from the seminal vesicles and prostate rather than the testicles, and the World Health Organization's current lower reference limit is 1.4 mL. Supplements & nutrients Semen volume supplements Semen volume supplements are products that combine nutrients such as zinc, L-arginine and lycopene with herbs such as maca and ashwagandha. Research on these ingredients covers sperm quality, erections and hormones, and some studies have also measured semen volume. Semen & ejaculation Seminal plasma Seminal plasma is the fluid, non-cellular part of semen: secretions from the testes, epididymis, seminal vesicles, prostate and bulbourethral glands that carry, fuel and protect sperm. It makes up the great majority of every ejaculate. Semen & ejaculation Seminal vesicles The seminal vesicles are two small glands behind the bladder that produce most of the fluid in semen, about 65% of it, including fructose to fuel sperm and proteins that make semen briefly thicken after ejaculation. Hormones SHBG (sex hormone-binding globulin) SHBG (sex hormone-binding globulin) is a protein made by the liver that grips testosterone and oestradiol tightly in the blood. The more SHBG you have, the less of your testosterone is free to act on your tissues. Sperm & fertility Sperm concentration Sperm concentration is the number of sperm in each millilitre of semen, reported in millions per mL. The World Health Organization's 2021 lower reference limit is 16 million sperm per mL. Sperm & fertility Sperm count Sperm count is the total number of sperm in a single ejaculate, calculated by multiplying sperm concentration by semen volume. The World Health Organization's lower reference limit is 39 million sperm per ejaculate. Sperm & fertility Sperm DNA fragmentation Sperm DNA fragmentation is damage, in the form of breaks, to the genetic material carried inside sperm. It is reported as the percentage of sperm with damaged DNA, often called the DNA fragmentation index (DFI), and a standard semen analysis cannot detect it. Sperm & fertility Sperm morphology Sperm morphology is the percentage of sperm with a normal size and shape, judged under a microscope using strict criteria. The World Health Organization's 2021 lower reference limit is 4% normal forms, so most sperm in fertile men look imperfect. Sperm & fertility Sperm motility Sperm motility is the percentage of sperm in a sample that are moving, and how well they move. World Health Organization 2021 lower reference limits are 42% for total motility and 30% for progressive motility. Sperm & fertility Spermatogenesis Spermatogenesis is the process by which the testes turn stem cells into mature sperm. In humans it takes roughly 64 days from start to finish and is driven by the hormones FSH and testosterone.

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